Stabilisation of emulsions by interfacial polymerisation of poloxamer surfactant derivatives |
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| Authors: | T. K. Law A. T. Florence T. L. Whateley |
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| Affiliation: | (1) Present address: Department of Pharmacy, University of Strathclyde, Glasgow, Scotland |
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| Abstract: | A method of increasing the stability ofo/w emulsions and providing a potential additional barrier to drug release from the oil droplets is described. Diacryloyl derivatives of non-ionic block copolymers (poloxamers) have been used to stabilise isopropyl myristate in water emulsions. Cross-linking of these stabilisers at the oil-water interface produces a polymeric region which increases the stabilityo/w emulsions to centrifugation and of thew/o emulsions to creaming. |
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| Keywords: | Emulsion stabilisation interfacial polymerisation surfactant polymerisation poloxamer |
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