Synthesis of 6-Heterocyclically Appended Tri- O-methyl Protected 6-Desmethyl Emodin Derivatives |
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Authors: | Tarek A Salama Bernd Lackner and Heinz Falk |
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Institution: | (1) Institute of Organic Chemistry, Johannes Kepler University, A-4040 Linz, Austria |
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Abstract: | A convenient synthesis of several 6-heterocyclically appended tri-O-methyl 6-desmethyl emodin derivatives including the tetrazolyl, oxazolyl, oxazolinyl, benzimidazolyl, benzoxazolyl, and benzothiazolyl derivatives of potential biological and medicinal interest was achieved starting from the tri-O-methyl protected emodin aldehyde or nitrile. In addition, these derivatives could serve as synthons for heterocyclic hypericin derivatives. |
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