首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Kappa carrageenan-g-poly (acrylic acid)/SPION nanocomposite as a novel stimuli-sensitive drug delivery system
Authors:Ghasem Rezanejade Bardajee  Zari Hooshyar  Freshteh Rastgo
Institution:1. Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran
Abstract:In this article, a novel triple-stimuli hydrogel was prepared by simultaneous formation of super paramagnetic iron oxide nanoparticles (SPION) and crosslinking of poly (acrylic acid) grafted onto kappa carrageenan (κC-g-PAA). The structure, thermal stability, surface morphology, and magnetic property of the κC-g-PAA/SPION hydrogel were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy with energy dispersive X-ray analysis (SEM–EDAX), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Moreover, swelling capacity of the obtained hydrogel was measured at different temperature, pH, and magnetic-field to assess the sensitivity of κC-g-PAA/SPION hydrogel. This synthetic hydrogel was also examined as a controlled drug delivery system and defrasirox release was investigated at different temperature, pH, and magnetic-field. The in vitro antibacterial activity of κC-g-PAA/SPION hydrogel was studied against Escherichia coli and Staphylococcus aureus bacteria where the results showed no antibacterial activity of this new hydrogel. In vitro biocompatibility experiments were undertaken using human bladder epithelial cell line HTB 5637. These results indicated the synthesized κC-g-PAA/SPION hydrogel are nontoxic that will be useful for biomedical applications.
Figure
We introduce a novel triple-stimuli and biocompatible kappa-carrageenan-g-poly(acrylic acid)/SPION nanocomposite as a drug delivery system
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号