Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group |
| |
| Authors: | Yang Yiqing Lin Yun Rao Yu |
| |
| Institution: | Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China. |
| |
| Abstract: | An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
