Copper phosphoramidite-catalyzed enantioselective desymmetrization of meso-cyclic allylic bisdiethyl phosphates |
| |
Authors: | Piarulli Umberto Claverie Christelle Daubos Philippe Gennari Cesare Minnaard Adriaan J Feringa Ben L |
| |
Institution: | Dipartimento di Scienze Chimiche, Fisiche e Matematiche, Università dell'Insubria, via Valleggio 11, I- 22100 Como, Italy. umberto.piraulli@uninsubria.it |
| |
Abstract: | reaction: see text] A highly regio-, diastereo-, and enantioselective desymmetrization of five-, six-, and seven-membered meso-cyclic allylic bis-diethyl phosphates (2a, 2b, and 2c, respectively) was obtained with diethylzinc, using catalytic amounts of Cu(OTf)](2).C(6)H(6) and phosphoramidite ligands 5. Enantiomeric excesses of up to 87, 94, and >98% were obtained for the addition of diethylzinc to cyclopentene, cyclohexene, and cycloheptene bis-diethyl phosphates, respectively. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|