The first silver-catalyzed three-component coupling of aldehyde, alkyne, and amine |
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| Authors: | Wei Chunmei Li Zigang Li Chao-Jun |
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| Institution: | Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA. |
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| Abstract: | reaction: see text] Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required. |
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