Symbiotic relationship between brain structure and dynamics |
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| Authors: | Mikail Rubinov Olaf Sporns Cees van Leeuwen Michael Breakspear |
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| Institution: | (1) Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia;(2) Mental Health Research Division, Queensland Institute of Medical Research, Brisbane, Australia;(3) CSIRO Information and Communication Technologies Centre, Sydney, Australia;(4) Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA;(5) Laboratory for Perceptual Dynamics, RIKEN Brain Science Institute, Saitama, Japan;(6) Royal Brisbane and Women's Hospital Mental Health Service, Brisbane, Australia |
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| Abstract: | Background Brain structure and dynamics are interdependent through processes such as activity-dependent neuroplasticity. In this study,
we aim to theoretically examine this interdependence in a model of spontaneous cortical activity. To this end, we simulate
spontaneous brain dynamics on structural connectivity networks, using coupled nonlinear maps. On slow time scales structural
connectivity is gradually adjusted towards the resulting functional patterns via an unsupervised, activity-dependent rewiring
rule. The present model has been previously shown to generate cortical-like, modular small-world structural topology from
initially random connectivity. We provide further biophysical justification for this model and quantitatively characterize
the relationship between structure, function and dynamics that accompanies the ensuing self-organization. |
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