| 3-溴-1,6-萘啶-5(6H)-酮的合成 |
| |
| 引用本文： | 朱卓越,黄淑芳.3-溴-1,6-萘啶-5(6H)-酮的合成[J].华中师范大学学报(自然科学版),2012,46(4):432-434. |
| |
| 作者姓名： | 朱卓越 黄淑芳 |
| |
| 作者单位： | 1. 湖南中烟工业有限公司,长沙,410007
2. 长沙环保职业技术学院,长沙,410004 |
| |
| 摘 要： | 报道了以1,1,3,3-四甲氧基丙烷和2-氰基乙酰胺为起始原料,经胺化、溴化、Sonogashira选择偶联、氰基水解等反应合成5-溴-2-(2,2-二甲氧基乙烯基)-烟碱酰胺(8),8经环化反应得到化合物3-溴-1,6-萘啶-5(6 H)-酮(9),共历经8步反应,总产率约为10%.化合物(9)的结构经过1 HNMR、13 C NMR、MS和EA等表征.
|
| 关 键 词： | 1 1 3 3-四甲氧基丙烷 2-腈基乙酰胺 胺化 溴化 Sonogashira选择偶联 |
Synthesis of 3-bromo-1,6-naphthyridin-5 (6H)-one |
| |
| ZHU Zhuoyue
,
HUANG Shufang.Synthesis of 3-bromo-1,6-naphthyridin-5 (6H)-one[J].Journal of Central China Normal University(Natural Sciences),2012,46(4):432-434. |
| |
| Authors: | ZHU Zhuoyue HUANG Shufang |
| |
| Institution: | 1.China Tobacco Hunan Industrial Co.Ltd,Changsha 410007; 2.Changsha Environmental Protection College,Changsha 410004) |
| |
| Abstract: | The new compound 3-bromo-1,6-naphthyridin-5(6H)-one was synthesized in the total yield of 10% after eight reactions,by the cyclization of the compound 7 under the catalysis of the Tol-OH.The compound 7 was prepared from 1,1,3,3-tetramethoxypropane and 2-cyanoacetamide by amidation,bromination,Sonogashira selective coupling,hydrolyzation of cyanide.The structure of compound 9 was confirmed correctly by 1H NMR,13C NMR,MS and EA. |
| |
| Keywords: | 1 1 3 3-tetramethoxypropane 2-cyanoacetamide amidation bromination Sonogashira selective coupling |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《华中师范大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《华中师范大学学报(自然科学版)》下载免费的PDF全文 |
|
