| N-{[(5-对氯苯基)-1,3,4-噻二唑]-2-基}-2-芳氧烟酰胺的合成及生物活性 |
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| 引用本文： | 周梦成,张 池,曹 肖,陈 卓,乐慧庆,胡景城,龚银香.N-{[(5-对氯苯基)-1,3,4-噻二唑]-2-基}-2-芳氧烟酰胺的合成及生物活性[J].华中师范大学学报(自然科学版),2012,46(2):170-173. |
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| 作者姓名： | 周梦成 张 池 曹 肖 陈 卓 乐慧庆 胡景城 龚银香 |
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| 作者单位： | 长江大学化学与环境工程学院,湖北荆州,434023 |
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| 基金项目： | 国家大学生创新实验项目，湖北省教育厅重点项目 |
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| 摘 要： | 利用酚与2-氯烟酸在氢化钠作用下得到中间体芳氧基烟酸.芳氧基烟酸经酰氯化,再与取代2-氨基-1,3,4-噻二唑作用,合成了8个未见文献报道的含取代1,3,4-噻二唑的芳氧烟酰胺类化合物.目标化合物的结构经红外光谱、核磁共振氢谱和元素分析等确证.初步的生物活性测试表明,部分目标化合物具有良好的除草活性.
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| 关 键 词： | 芳氧基烟酸 酰胺 合成 除草活性 |
Synthesis and biological activities of N- { [ (5-p-chlorophenyl) -1,3,4-thiadiazole]-2-yl }-2-aryloxy nicotinamide |
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| ZHOU Mengcheng
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ZHANG Chi
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CAO Xiao
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CHEN Zhuo
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YUE Huiqing
,
HU Jingcheng
,
GONG Yinxiang.Synthesis and biological activities of N- { [ (5-p-chlorophenyl) -1,3,4-thiadiazole]-2-yl }-2-aryloxy nicotinamide[J].Journal of Central China Normal University(Natural Sciences),2012,46(2):170-173. |
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| Authors: | ZHOU Mengcheng ZHANG Chi CAO Xiao CHEN Zhuo YUE Huiqing HU Jingcheng GONG Yinxiang |
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| Institution: | (School of Chemistry and Environmental Engineering,Yangtze University,Jingzhou,Hubei 434023) |
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| Abstract: | Aryloxynicotinic acid was synthesized by the reaction of 2-chlorlnicotinic acid with phenol in the presence of NaH.Eight new aryloxynicotinamide containing 1,3,4-thiadiazole ring have been synthesized via chlorination,followed with 5-amino-1,3,4-thiadiazole.Their structures were confirmed by IR spectra,1H NMR and elemental analysis.The biological activity tests showed that some target compounds displayed good herbicidal activities. |
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| Keywords: | aryloxy acid amide synthesis herbicidal activity |
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