The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug |
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| Authors: | Davies Murray S Berners-Price Susan J Cox John W Farrell Nicholas |
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| Institution: | Department of Chemistry, University of Western Australia, Crawley, WA 6009, Australia. |
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| Abstract: | The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host. |
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