Definitive identification of cysteine and glutathione complexes of bismuth by mass spectrometry: assessing the biochemical fate of bismuth pharmaceutical agents |
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Authors: | Burford Neil Eelman Melanie D Mahony David E Morash Michael |
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Affiliation: | Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada. neil.burford@dal.ca |
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Abstract: | Solutions containing BiCl3, bismuth subsalicylate or Bi(NO3)3 with L-cysteine, DL-homocysteine, D-methionine or glutathione have been examined by electrospray mass spectrometry. Prominent peaks are assigned to bismuth complexes of these biomolecules and provide insight towards understanding the bioactivity of bismuth compounds. |
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