Site-specific cleavage of human telomerase RNA using PNA-neocuproine.Zn(II) derivatives |
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| Authors: | Whitney Andrew Gavory Gérald Balasubramanian Shankar |
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| Institution: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW. |
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| Abstract: | Here we report the synthesis of a novel PNA based neocuproine.Zn RNA cleaving agent; we demonstrate that such agents sequence specifically cleave a synthetic RNA target and in particular the RNA component of human telomerase. |
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