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Synthetic study of yonarolide: stereoselective construction of the tricyclic core |
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| Authors: | Yohei UedaHideki Abe Kazuo IguchiHisanaka Ito |
| Affiliation: | School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
| Abstract: | Stereoselective construction of the tricyclic core of yonarolide (1), a marine norditerpenoid, was achieved. This synthetic route includes a Diels-Alder reaction and an intramolecular aldol condensation. It also involves efficient epimerization through a retro-Michael reaction-Michael addition and will be applicable to the total synthesis of 1. |
| Keywords: | Yonarolide Diels-Alder reaction Intramolecular aldol condensation Tricyclic core Retro-Michael-Michael addition |
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