Pd-catalyzed alkyl to aryl migration and cyclization: an efficient synthesis of fused polycycles via multiple C-H activation |
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Authors: | Huang Qinhua Fazio Alessia Dai Guangxiu Campo Marino A Larock Richard C |
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Institution: | Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. |
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Abstract: | A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed. This process involves 1,4-palladium alkyl to aryl migrations via through-space C-H activation, followed by intramolecular arylation or an intermolecular Heck reaction providing a very efficient way to synthesize fused ring systems. |
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