| Synthesis of Conformationally Locked 2＇-Deoxy-2＇-nucleobase-5＇- Isonucleosides: 2＇-Deoxy-2＇-nucleobase-5＇ deoxy-1＇, 4＇ :3＇, 6＇-dianhydro-D-mannitol |
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| 作者单位： | TIAN Xiao-bing,ZHANG Ling,MIN Ji-mei,ZHANG Li-he(School of Pharmaceutical Sciences, Beijing Medical University,);LU Yang,JIANG Reng-wang,ZHENG Qi-Tai(Institute of Materia Medica, Peking Union Medical College ＆Chinese Academy of Medical Sciences,)
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| 摘 要： | Novel bicyclic isonucleosides, 2＇ -deoxy- 2＇ -nucleobase- 5＇ -deoxy- 1＇ , 4＇ : 3＇ , 6＇ -dianhydro D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con formation.
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| 收稿时间： | 2000-05-01 |
Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol |
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| Authors: | TIAN Xiao-bing ZHANG Ling MIN Ji-mei ZHANG Li-he LU Yang JIANG Reng-wang ZHENG Qi-Tai |
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| Institution: | 1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China;
2. Institute of Materia Medica, Peking Union Medical College ＆Chinese Academy of Medical Sciences, Beijing 100050, P. R. China |
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| Abstract: | Novel bicyclic isonucleosides, 2'-deoxy- 2'-nucleobase- 5'-deoxy- 1', 4': 3', 6'-dianhydro D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con formation. |
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| Keywords: | Bicyclic isonucleoside Locked conformation Synthesis |
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