Alkenes as ketol surrogates-a new approach toward enantiopure acyloins |
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Authors: | Plietker Bernd |
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Affiliation: | Organische Chemie II, Fachbereich Chemie, Universit?t Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. plietker@pop.uni-dortmund.de |
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Abstract: | [reaction: see text] Enantiopure alpha-hydroxy ketones are important building blocks in organic synthesis. This paper describes the use of cyclic ruthenates for the first catalytic regioselective oxidation of vic-diols to alpha-ketols. The combination of RuCl3/Oxone/NaHCO3 was used in a two-step sequence of asymmetric dihydroxylation and regioselective monooxidation for the synthesis of a broad scope of enantiopure acyloins. |
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