cADPR analogues: effect of an adenosine 2'- or 3'-methoxy group on conformation |
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| Authors: | Graham Steven M Macaya Daniel J Sengupta Raghuvir N Turner Kevin B |
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| Affiliation: | Department of Chemistry, St. John's University, Jamaica, New York 11439, USA. grahams@stjohns.edu |
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| Abstract: | [structure: see text] The 2'-OMe-A (2) and 3'-OMe-A (3) analogues of the calcium release agent cADPR (1) were prepared and their solution structures studied by NMR spectroscopy. Compared to 1, 2 shows a shift in its A ring conformation and changes in its R ring N:S and gammat:gamma+ ratios, while 3 displays a significant change in the conformation of its A ring gamma-bond. |
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