Oxidation of guanine bases mediated by a manganese-porphyrin-oligonucleotide conjugate onto a G-rich DNA target: 8-oxo-7,8-dihydroguanine is not the major lesion |
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| Institution: | 1. Ivanovo State University of Chemistry and Technology, Sheremetevsky Ave., 7, 153000 Ivanovo, Russia;2. G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia |
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| Abstract: | The oxidative alkali-labile G lesions mediated by manganese porphyrin oligonucleotide conjugate on a DNA target could not be attibuted to the formation of 8-oxo-7,8-dihydroguanine since they were not substrate of the Fpg protein. In order to identify the nature of these lesions, an analysis of the oxidized derivatives of 2′-deoxyguanosine, imidazolone and oxazolone, generated by photooxidation, was efficiently performed by using the positive electrospray ionisation-mass spectrometry method. |
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