Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu(5)-enkephalin |
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Authors: | Miao Weishi Chan Tak-Hang |
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Affiliation: | Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6. |
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Abstract: | A new strategy for the synthesis of oligopeptides was developed using an ionic liquid as a soluble support. The efficiency of this ionic liquid-phase approach was demonstrated by the synthesis of a bioactive pentapeptide, Leu(5)-enkephalin, in good yield and reasonable purity. The structures and purities of the reaction intermediates in each step were verified easily by routine spectroscopic analysis, and no chromatographic procedures were needed during the synthesis. |
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