Ruthenium and enzyme-catalyzed dynamic kinetic resolution of alcohols |
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| Authors: | R. Karvembu R. Prabhakaran M. Muthu Tamizh K. Natarajan |
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| Affiliation: | aDepartment of Chemistry, National Institute of Technology, Tiruchirappalli 620015, India;bDepartment of Chemistry, Bharathiar University, Coimbatore 641046, India |
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| Abstract: | Ruthenium acts as a good catalyst for the racemization reaction of secondary alcohols and amines. Ruthenium-catalyzed racemization is coupled with enzymatic kinetic resolution to prepare chiral compounds in 100% theoretical yield. Ten ruthenium complexes (1–10) act as a good catalyst the for racemization reaction and are also compatible with DKR process. Two other ruthenium complexes [RuCl2(PPh3)3] and [Cp*RuCl(COD)] are active for racemization reaction but their successful compatibility with DKR has not yet been reported. Ru/γ-Al2O3 and Ru–HAP are the heterogeneous catalysts used for the racemization reaction. They have also not been employed for DKR process. Polymer supported ruthenium is employed as a reusable racemization catalyst for aerobic DKR of alcohols. |
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| Keywords: | Ruthenium Racemization Dynamic kinetic resolution Chiral |
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