Blue-emitting PEGylated hyperbranched PAMAM: transformation of cross-linked micelles to hollow spheres controlled by the PEG grafting density |
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Authors: | Jie Chen Jia Guo Baisong Chang Wuli Yang |
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Institution: | (1) State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China;(2) Department of Macromolecular Science, Fudan University, Shanghai, 200433, China; |
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Abstract: | Here we reported the synthesis of polyethylene glycol 2000 monomethyl ether (PEG)ylated hyperbranched poly (amido amine) (h-PAMAM-g-PEG) and the study of an elaborate control over the structure transition by solvents. The double hydrophilic hyperbranched
copolymers could form micelles with h-PAMAM core and solvophilic PEG shell in tetrahydrofuran (THF). It was found that the micellization stage was prolonged if
more PEG chains were anchored onto h-PAMAM cores. After cross-linking the h-PAMAM cores, well-dispersed hollow spheres were obtained when the micelles were transferred into water from THF. More grafted
PEG chains on h-PAMAM may prohibit the creation of a hollow cage upon the swelling of the hydrophilic h-PAMAM cores. Such engineered hollow spheres also retained the pH-sensitive fluorescence characteristic, identical with the
luminescent behavior of the free h-PAMAM molecules. H-PAMAM-g-PEG hollow spheres with pH-sensitive fluorescence have a potential application as a drug delivery vehicle for chemotherapy. |
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