|
|||||
|
|
| 配合物二乙基锡N-[(2-氧苯基)亚甲基]甘氨酸酯的合成、结构表征和生物活性 | |
| 引用本文： | 田来进,杨红军,郑晓亮,孙玉希,倪中海,钱伯初. 配合物二乙基锡N-[(2-氧苯基)亚甲基]甘氨酸酯的合成、结构表征和生物活性[J]. 无机化学学报, 2009, 25(7): 1205-1211 |
| 作者姓名： | 田来进 杨红军 郑晓亮 孙玉希 倪中海 钱伯初 |
| 作者单位： | 1. 曲阜师范大学化学系,曲阜,273165;山东大学化学系,济南,250100 2. 曲阜师范大学化学系,曲阜,273165 3. 浙江省医学科学院药物研究所,杭州,310013 4. 山东大学化学系,济南,250100 |
| 基金项目： | 山东省博士后创新项目专项基金，山东大学胶体与界面化学教育部重点实验室开放基金，国家自然科学基金 |
| 摘 要： | 合成了5个新的二乙基锡N-[(2-氧苯基)亚甲基]甘氨酸酯(CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2COO)(X,Y=H,H,1;H,Cl,2;H,Br,3;Cl,Cl,4;Br,Br,5),利用元素分析、IR、1H和129Sn NMR表征了其结构.通过X-射线单晶衍射测定了1和4的晶体结构.化合物1的晶体属单斜晶系,P21空间群;化合物4的晶体属三斜晶系,P1空间群.2个化合物均为由羧基桥联形成的[Sn3O6C3]十二元大环三聚体结构,锡原子的配位构型为六配位[SnC2NO3]畸变八面体.生物活性测试结果表明,化合物5对3种人癌细胞HeLa、CoLo205和MCF-7及大肠杆菌均有抑制活性. |
| 关 键 词： | 有机锡羧酸酯 甘氨酸 体外抗癌活性 晶体结构 |
Synthesis, Structural Characterization and Biological Activity of the Complex Diethyltin N-[(2-oxyphenyl)methylene]glycinates |
|
| TIAN Lai-Jin,YANG Hong-Jun,ZHENG Xiao-Liang,SUN Yu-Xi,NI Zhong-Hai and QIAN Bo-Chu. Synthesis, Structural Characterization and Biological Activity of the Complex Diethyltin N-[(2-oxyphenyl)methylene]glycinates[J]. Chinese Journal of Inorganic Chemistry, 2009, 25(7): 1205-1211 | |
| Authors: | TIAN Lai-Jin YANG Hong-Jun ZHENG Xiao-Liang SUN Yu-Xi NI Zhong-Hai QIAN Bo-Chu |
| Affiliation: | Department of Chemistry, Qufu Normal University, Qufu, Shandong 273165; Department of Chemistry, Shandong University, Jinan 250100,Department of Chemistry, Qufu Normal University, Qufu, Shandong 273165,Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013,Department of Chemistry, Qufu Normal University, Qufu, Shandong 273165,Department of Chemistry, Shandong University, Jinan 250100 and Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013 |
| Abstract: | Five new diethyltin N-[(2-oxyphenyl)methylene]glycinates, (CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2 COO) (X, Y=H, H, 1; H, Cl, 2; H, Br, 3; Cl, Cl, 4; Br, Br, 5), have been prepared and characterized by elemental analysis, IR, 1H and 119Sn NMR spectra. The crystal structures of 1 and 4 have been determined. The crystal for 1 belongs to monoclinic space group P21, and the crystal for 4 belongs to triclinic space group P1. The two compounds have a 12-membered macrocyclic structure with a trimeric [Sn3O6C3] core. Each tin atom is six-coordinated in distorted [SnC2NO3] octahedron geometry. Bioassay results show that the compound 5 has in vitro anti-tumor activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7 and anti-bacterial activity against E. coli. CCDC: 729956, 1; 729957, 4. |
| Keywords: | organotin carboxylate glycine in vitro antiturnor activity crystal structure |
| 本文献已被 万方数据 等数据库收录！ | |
| 点击此处可从《无机化学学报》浏览原始摘要信息 | |
| 点击此处可从《无机化学学报》下载全文 | |