Artificial Nucleotide-containing Aptamers Used in Tumor Therapy |
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| Authors: | QIN Xinyuan SU Yuanye TAN Jie YUAN Quan |
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| Affiliation: | 1. Institute of Chemical Biology and Nanomedicine(ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, P. R. China;2. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China |
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| Abstract: | The high pharmaceutical cost and multi-drug resistance in tumor therapeutic agents hinder the further application of chemotherapy in tumor therapy. Artificial modified nucleic acid aptamers have the advantages of high binding affinity, programmability, and easy synthesis. Thus, the rational design of artificial modified aptamers is expected to provide a versatile platform for the optimization of chemotherapy agents. In this review, we summarize the modification strategies and the application of the artificial modified nucleotide-containing aptamers, aiming to provide a promising step toward aptamer-related chemotherapeutic agents. |
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| Keywords: | Aptamer Artificial nucleotide Functional nucleic acid |
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