| Programmable Assembly of DNA-protein Hybrid Structures |
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| 作者姓名： | LI Xue YANG Donglei SHEN Luyao XU Fan WANG Pengfei |
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| 作者单位： | Institute of Molecular Medicine |
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| 基金项目： | Supported by the National Natural Science Foundation of China(No.21974086). |
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| 摘 要： | DNA is the genetic information carrier for most known living organisms on Earth,while proteins are the functional component that carry out most biological processes.Many natural machineries are DNA-protein hybrid complexes to cooperatively and efficiently conduct sophisticated biological tasks.It has drawn increasing interest to the research field to construct artificial DNA-protein hybrid structures towards a variety of applications including biological studies,nanofabrication,biomedical research,etc.In this regard,here in this report we reviewed the up-to-date progress on making DNA-protein hybrid structures,with a particular focus on DNA nanotechnology-enabled programmable assembly of DNA-protein hybrid structures.
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| 关 键 词： | DNA NANOTECHNOLOGY SELF-ASSEMBLY DNA-protein CONJUGATION DNA-protein hybrid structure |
| 收稿时间： | 2019-11-06 |
Programmable Assembly of DNA-protein Hybrid Structures |
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| LI Xue,YANG Donglei,SHEN Luyao,XU Fan,WANG Pengfei.Programmable Assembly of DNA-protein Hybrid Structures[J].Chemical Research in Chinese University,2020,36(2):211-218. |
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| Authors: | LI Xue YANG Donglei SHEN Luyao XU Fan WANG Pengfei |
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| Institution: | Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China |
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| Abstract: | DNA is the genetic information carrier for most known living organisms on Earth, while proteins are the functional component that carry out most biological processes. Many natural machineries are DNA-protein hybrid complexes to cooperatively and efficiently conduct sophisticated biological tasks. It has drawn increasing interest to the research field to construct artificial DNA-protein hybrid structures towards a variety of applications including biological studies, nanofabrication, biomedical research, etc. In this regard, here in this report we reviewed the up-to-date progress on making DNA-protein hybrid structures, with a particular focus on DNA nanotechnology-enabled programmable assembly of DNA-protein hybrid structures. |
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| Keywords: | DNA nanotechnology Self-assembly DNA-protein conjugation DNA-protein hybrid structure |
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