| Synthesis of N-Aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds |
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| 作者姓名： | WANG Duo-zhi and CAO Ling-hua ** . |
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| 作者单位： | WANG Duo-zhi 1 and CAO Ling-hua 1，2** 1. Department of Chemistry，Xinjiang University，Urumqi 830046，P. R. China; 2. State Key Laboratory of Elemento-organic Chemistry，Nankai University，Tianjin 300071，P. R. China |
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| 基金项目： | theNationalNaturalScienceFoundationofChina(Nos.29962002and20462006). |
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| 摘 要： | Introduction Somepyridazineshavebeenexaminedforac- tivityagainstsporozoanandflagellateparasitesand forantiamebicactivity1]. 6-Aryl-4,5-dihydro-3(2H)-pyridazinonesex- hibitvariousbiologicalpropertiesincludingreduc- tionofbloodpressure,inhibitionofplateletaggre- gation,antiinflammation,andstrongplateletag- gregationinhibitingactioncoupledwithahypoten- siveaction.Italsopossessesweakpositiveinotrop- icactivityforthemanagementofcongestiveheart failure.Threepara-substitueddihydropyridazi- nonesare…
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