The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium |
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| Authors: | Carlos Spuch Eva Carro |
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| Institution: | (1) Neuroscience Group, Research Institute Hospital, 12 de Octubre, Madrid, Spain;(2) Department of Pathology and Neuropathology, University Hospital of Vigo (CHUVI), Vigo, Spain;(3) Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Madrid, Spain |
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| Abstract: | Background The presence of neurotrophins and their receptors Trk family has been reported in the choroid plexus. High levels of Nerve
Growth Factor (NGF), Neurotrophin-4 (NT-4) and TrkB receptor were detected, while nothing was know about p75 neurotrophin
receptor (p75NTR) in the choroid plexus epithelial cells. In neurons, p75NTR receptor has a dual function: promoting survival
together with TrkA in response to NGF, and inducing apoptotic signaling through p75NTR. We postulated that p75NTR may also
affect the survival pathways in the choroid plexus and also undergoes regulated proteolysis with metalloproteases. |
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