Microgravimetric flow analysis of nucleic acid based on adsorption of nanoparticle-bioconjugate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Microgravimetric flow analysis of nucleic acid based on adsorption of nanoparticle-bioconjugate

Authors:	Z.-H.?Mo author-information" > author-information__contact u-icon-before" > mailto:zhihmo@cqu.edu.cn" title=" zhihmo@cqu.edu.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Y.-L.?Liang,H.-L.?Wang,F.-W.?Liu,Y.-X.?Xue

Affiliation:	(1) College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, PR China;(2) Chengdu Enwei Pharmaceutical Co. Ltd., Chengdu, 610041 Sichuan, PR China;(3) Chongqing University of Medical Science, Chongqing, 400016, PR China

Abstract:	A novel nanoparticle-bioconjugate has been prepared by specific hybridization of the target with complementary thiol-labeled and nanoparticle-labeled probes. The rapid adsorption of the nanoparticle-bioconjugate onto a gold surface via a thiol-gold reaction was monitored in real-time using a quartz crystal microbalance, and used to perform microgravimetric flow analysis of nucleic acid for the first time. This innovative assay is highly reproducible and sensitive, and shows great promise for clinical applications.

Keywords:	Nanoparticle Bioconjugate Microgravimetry DNA detection
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