Stereoselective synthesis of the C1-C13 fragment of 2,3-dihydrodorrigocin A |
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| Authors: | Le Brazidec Jean-Yves Gilson Charles A Boehm Marcus F |
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| Institution: | Department of Chemistry and Biology, Conforma Therapeutics Corporation, 9393 Towne Centre Drive, Suite 240, San Diego, California 92121, USA. jlebrazidec@conformacorp.com |
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| Abstract: | Chemical reaction: see text] The first synthesis of the C1-C13 fragment of 2,3-dihydrodorrigocin A has been achieved from 6-bromohexanoic acid in 14 linear steps and an overall yield of 2%. The configurations of the stereogenic centers C8, C9, and C10 have been determined to be the same as for migrastatin. |
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