| Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils |
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| 引用本文： | Ai Ming Yu and Hua Zheng YANG(State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071)Zhen Pu ZHANG(State Key Laboratory of Functional Polymeric Materials for AdsorPtion and Separation,Nankai University,Tianin 3OOO7l. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. 中国化学快报, 1998, 0(2) |
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| 作者姓名： | Ai Ming Yu and Hua Zheng YANG(State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071)Zhen Pu ZHANG(State Key Laboratory of Functional Polymeric Materials for AdsorPtion and Separation Nankai University Tianin 3OOO7l |
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| 作者单位： | Ai Ming Yu and Hua Zheng YANG(State Key Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071 |
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| 摘 要： | Combinatorialchemistryhasemergedasanefficienttoolforchedriststosynthesize"comPoundslibraries"fortheraPididentificationandoPtforizationofnewleads-lSolidphaseorganicsynthesisprovidesaraPidmeansforpreparationofcomPoundslibraries,andhasbeenusedfortheconstrUctionofoligomericcomPounds,'andsmallorganicmoleculessuchasbenzodiazepine,'9-lactams,'andquinolones.'ThemajortargetfortheinhibitionofphotosystemII(PSII)istheDlprotein,apolyPePtidewithamolecularweightof32kDa.'Wehavedevelopedmodelsoftheher-b…
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Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils |
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| Ai Ming Yu and Hua Zheng YANG. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. Chinese Chemical Letters, 1998, 0(2) |
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| Authors: | Ai Ming Yu and Hua Zheng YANG |
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| Abstract: | A general method for the solid phase synthesis of hydro-uracils and thiouracils is de-scribed. Resino ester 2 reacts with various primary amines to give secondary amines 3, Which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem II D1 protein inhibitors. |
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| Keywords: | Solid Phase Synthesis Hydro-Uracils and Thiouracils Photosynthesis Inhibitors |
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