| Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils |
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| 作者姓名： | Ai Ming Yu and Hua Zheng YANG |
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| 作者单位： | Ai Ming Yu and Hua Zheng YANG(State Key Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071 |
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| 摘 要： | Combinatorialchemistryhasemergedasanefficienttoolforchedriststosynthesize"comPoundslibraries"fortheraPididentificationandoPtforizationofnewleads-lSolidphaseorganicsynthesisprovidesaraPidmeansforpreparationofcomPoundslibraries,andhasbeenusedfortheconstrUctionofoligomericcomPounds,'andsmallorganicmoleculessuchasbenzodiazepine,'9-lactams,'andquinolones.'ThemajortargetfortheinhibitionofphotosystemII(PSII)istheDlprotein,apolyPePtidewithamolecularweightof32kDa.'Wehavedevelopedmodelsoftheher-b…
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Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils |
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| Ai Ming Yu and Hua Zheng YANG.Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J].Chinese Chemical Letters,1998(2). |
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| Authors: | Ai Ming Yu and Hua Zheng YANG |
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| Abstract: | A general method for the solid phase synthesis of hydro-uracils and thiouracils is de-scribed. Resino ester 2 reacts with various primary amines to give secondary amines 3, Which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem II D1 protein inhibitors. |
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| Keywords: | Solid Phase Synthesis Hydro-Uracils and Thiouracils Photosynthesis Inhibitors |
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