Phosphine-catalyzed alpha-P-addition on activated alkynes: A new route to P-C-P backbones |
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Authors: | Lecerclé Delphine Sawicki Marcin Taran Frédéric |
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Institution: | Service de Marquage Moléculaire et de Chimie Bioorganique, Commissariat à l'Energie Atomique, Gif sur Yvette, F-91191 France. |
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Abstract: | n-Tributylphosphine was found to efficiently catalyze the alpha-P addition of H-phosphonates, H-phosphinates, and H-phosphine oxide pronucleophiles on alkynes bearing phosphane oxide activating moieties. The reaction leads to 2-aryl-1-vinyl-1,1-diphosphane dioxide derivatives in good yields affording a new route to P-C-P backbones. The products of this reaction are easily converted to biologically important 1,1-bis-phosphonates analogues. |
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