| 基于群智能和冲突规避策略的基因-基因交互作用检测方法 |
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| 引用本文： | 刘天航,殷建平,赵志恒,詹宇斌.基于群智能和冲突规避策略的基因-基因交互作用检测方法[J].武汉大学学报(理学版),2011,57(6):472-476. |
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| 作者姓名： | 刘天航 殷建平 赵志恒 詹宇斌 |
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| 作者单位： | 国防科技大学计算机学院,湖南长沙,410073 |
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| 基金项目： | 国家自然科学基金(61170287)资助项目 |
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| 摘 要： | 针对当前检测基因-基因交互作用方法中存在的一些缺陷,提出一种基于群智能和冲突规避策略的基因-基因交互作用检测方法（DEIBSC）.以SNP（single nucleotide polymorphism）为研究对象,从大量SNP中选出具有显著基因-基因交互作用的SNP组.初始化多个SNP组作为初值,同时产生多条搜索路径,利用得分单调递增原则寻找问题的解,通过冲突规避策略和群智能动态调整搜索路径的方向,使得到的解更能反映基因-基因交互作用在基因组范围内分布的情况.在仿真数据和真实数据上的实验证实,本文方法在统计能力上可以和SNPHarvester方法相比,在效率上有明显优势,得到的结果能够更广泛地代表基因-基因交互作用在基因组的分布.
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| 关 键 词： | 全基因组关联研究 基因-基因交互作用 单核苷酸多态 群智能 冲突规避策略 |
DEIBSC:A Method for Detecting Gene-Gene Interactions Based on Swarm Intelligence and Collision Avoidance Strategy |
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| LIU Tianhang,YIN Jianping,ZHAO Zhiheng,ZHAN Yubin.DEIBSC:A Method for Detecting Gene-Gene Interactions Based on Swarm Intelligence and Collision Avoidance Strategy[J].JOurnal of Wuhan University:Natural Science Edition,2011,57(6):472-476. |
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| Authors: | LIU Tianhang YIN Jianping ZHAO Zhiheng ZHAN Yubin |
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| Institution: | LIU Tianhang,YIN Jianping,ZHAO Zhiheng,ZHAN Yubin(College of Computer,National University of Defense Technology,Changsha 410073,Hunan,China) |
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| Abstract: | In order to overcome the deficiencies of present methods for detecting gene-gene interactions,we propose a new method(DEIBSC) based on swarm intellegence and collision avoidance strategy.Focusing on SNPs,our method selects those SNP groups having significant gene-gene interactions from a mass of SNPs.It initializes a certain amount of SNP groups,and then generates multiple search paths.Using score monotone increasing principle and adjusting search paths dynamically,our method makes the solutions reflect the... |
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| Keywords: | genome-wide association study gene-gene interaction single nucleotide polymorphism swarm intelligence collision avoidance strategy |
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