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4-Hydroxyquinolin-2-ones. 45. Synthesis, Structure, and Biological Activity of N-Substituted 1H-4-Hydroxy-2-oxoquinoline-3-acetic Acid Amides |
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| Authors: | I. V. Ukrainets S. G. Taran O. L. Kamenetskaya O. V. Gorokhova L. V. Sidorenko A. V. Turov |
| Affiliation: | (1) National Pharmaceutical Academy of the Ukraine, Kharkov, 310002;(2) Taras Shevchenko University, Kiev, 252033, Ukraine |
| Abstract: | A preparative method is proposed for obtaining N-substituted 1H-4-hydroxy-2-oxoquinoline-3-acetic acid amides. X-Ray diffraction analysis of one of the synthesized compounds has been carried out. The effect of the obtained substances on thyroid gland function has been studied. |
| Keywords: | amides tetrahydrofuroquinoline quinoline-3-acetic acid X-ray diffraction analysis thyroid-stimulating activity |
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