MECHANISM OF INTERFERON ACTION——STRUCTURAL REQUIREMENT OF LIGAND AND CELLULAR SPECIFICITY |
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引用本文: | 李伯良,刘新垣.MECHANISM OF INTERFERON ACTION——STRUCTURAL REQUIREMENT OF LIGAND AND CELLULAR SPECIFICITY[J].中国科学B辑(英文版),1985(8). |
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作者姓名: | 李伯良 刘新垣 |
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作者单位: | Shanghai Institute of Biochemistry,Academia Sinica,Shanghai Institute of Biochemistry,Academia Sinica |
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摘 要: | We had reported the existence of 2'-5'P_3A_3 receptor on the peritoneal macrophages from Wistar rat. In this paper data are given to demonstrate that the ligand, for binding with 2'-5'P_3A_3 receptor and enhancing the phagocytosis of macrophages, must have a three-phosphate radical on its 5'-terminus and at least three adenylate residues in 2'-5'oligoadenylate. (~3H)-2'-5'P_3A_3 can also bind on macrophages from other animals; and the binding of (~3H)-2'-5'P_3A_3 on Hepatoma cell line 7402 is lower than that on macrophages; whereas it is very low (binding ratio less than 1%) on erythrocytes (from rabbit, rat and mouse) or human embryo lung fibroblast cells. The binding conditions of the ligand with 2'-5'P_3A_3 receptor have also been investigated.
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