无溶剂无催化条件下一锅合成芳酰基腈化合物

无溶剂无催化剂条件下，以芳香酸、二氯亚砜和铁氰化钾为原料，经氯化、氰化两步一锅合成了一系列芳酰基腈化合物。 考察了氰化过程中反应温度、反应时间对产率的影响。 实验结果表明，其最佳反应条件为：反应温度为180 ℃，反应时间为2 h，产物收率达71%~92%。 产物经IR、1H NMR和13C NMR分析确认。 本方法具有工艺操作简单、产率高、无溶剂无催化和环境友好等优点。

One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions

A series of aroyl cyanides was synthesized by nucleophilic substitution reactions of aromatic acids with thionyl chloride and potassium ferricyanide in one-pot under solvent-free and catalyst-free conditions. The effects of the reaction temperature and time on the yield of the products were investigated. The yields of aroyl cyanides were up to 71%~92% when the reactions were performed at 180 ℃ for 2 h. The structures of the products were confirmed by IR, 1H NMR and 13C NMR spectroscopy. This method has advantages of simple work-up procedure, high yield, and eco-friendly solvent-free and catalyst-free conditions.