| Synthesis and Crystal Structure of 2-Amino-3-ethoxycarbonyl-4-（4-chlorophenyl）-4H, 5H-pyrano-[3,2-c]-benzopyran-5-one |
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| 引用本文： | 冯友健,蒋虹,高原,屠树江,史达清.Synthesis and Crystal Structure of 2-Amino-3-ethoxycarbonyl-4-（4-chlorophenyl）-4H, 5H-pyrano-[3,2-c]-benzopyran-5-one[J].结构化学,2004,23(7):773-777. |
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| 作者姓名： | 冯友健 蒋虹 高原 屠树江 史达清 |
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| 作者单位： | FENG You-Jiana JIANG Honga GAO Yuanb TU Shu-Jianga② SHI Da-Qinga a (Department of Chemistry，Xuzhou Normal University，Key Laboratory of Biotechnology on Medical Plant of Jiangsu，Xuzhou，Jiangsu 221009，China) b (Department of Chemistry，Shenzhen University，Shenzhen，Guangdong 518060，China) |
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| 基金项目： | Supported by NNSFC (No. 20372057)，NSF of Jiangsu Province (No. BK2001142)，Jiangsu Education Department (No. 01KJB150008) and the Key Lab of Biotechnology for Medicinal Plants of Jiangsu Province (02AXL 14) |
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| 摘 要： | 1 INTRODUCTION The coumarins constitute an important class of bioactive natural products1]. They have been found to possess diverse biological properties including antimicrobial, insecticidal, estrogenic, anticoagulant and antithrombotic activities. Som…
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| 关 键 词： | 合成 晶体结构 2-氨基-3-乙酯基-4-（4-氯苯基）-4H 5H-吡喃-[3 2-c]-苯并吡喃-5-酮 微波辐射 香豆素 氰基乙酸酯 乙醛 |
Synthesis and Crystal Structure of 2-Amino- 3-ethoxycarbonyl-4-(4-chlorophenyl)-4H,5H-pyrano-[3,2-c]-benzopyran-5-one |
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| Institution: | Department of Chemistry,Xuzhou Normal University,Key Laboratoryof Biotechnology on Medical Plant of Jiangsu,Xuzhou,Jiangsu 221009,China;Department of Chemistry,Shenzhen University,Shenzhen,Guangdong 518060,China |
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| Abstract: | The title compound 2-amino-3-ethoxycarbonyl-4-(4-chlorophenyl)-4H,5H-pyrano-3,2-c]-benzopyran-5-one (C21H16ClNO5,Mr = 397.80) has been synthesized and characterized by X-ray crystallography.It crystallizes in triclinic,space group P1 with a = 5.756(1),b = 10.099(1),c = 17.106(3)(A),α = 80.49(1),β = 83.13(1),γ = 80.07(1)o,V = 961.8(2)(A)3,Dc = 1.374 g/cm3,μ = 0.231 mm-1,Z = 2,F(000) = 412,the final R = 0.0369 and wR = 0.0947.In the molecule the pyran ring is of boat conformation.The intermolecular hydrogen bonds of N-H…O(5)(-x+2,-y+1,-z+1) and N-H…Cl (x+1,y-1,z) as well as intramolecular hydrogen bond N-H…O(5) are found. |
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| Keywords: | microwave irradiation benzopyran coumarin aldehyde ether cyanoacetate crystal structure |
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