Synthesis and NMR elucidation of homoisoflavanone analogues |
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| Authors: | Mahidansha Shaikh Katja Petzold Hendrik G Kruger Karen du Toit |
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| Institution: | (1) School of Chemistry, University of KwaZulu-Natal, Durban, South Africa;(2) School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban, South Africa; |
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| Abstract: | A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one
in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported. The use of 2D NMR techniques
(COSY, NOESY, HSQC and HMBC) proved to be very useful tools in the elucidation of homoisoflavanone analogues. The homoisoflavanone
analogues exhibit an AA′BB′ spin pattern in the ring B of the homoisoflavanone. These homoisoflavanone analogues are potential
antifungal and anti-inflammatory agents. |
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