Differential inhibition of postnatal brain,spinal cord and body growth by a growth hormone antagonist期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Differential inhibition of postnatal brain,spinal cord and body growth by a growth hormone antagonist

Authors:	DL?McIlwain author-information" > author-information__contact u-icon-before" > mailto:dlmc@med.unc.edu" title=" dlmc@med.unc.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,VB?Hoke,JJ?Kopchick,CR?Fuller,PK?Lund

Affiliation:	(1) Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, 27599 Chapel Hill, NC, USA;(2) Department of Biological Sciences, Molecular and Cell Biology Program, and the Edison Biotechnology Institute, Ohio University, 45701 Athens, Ohio, USA

Abstract:	Background Growth hormone (GH) plays an incompletely understood role in the development of the central nervous system (CNS). In this study, we use transgenic mice expressing a growth hormone antagonist (GHA) to explore the role of GH in regulating postnatal brain, spinal cord and body growth into adulthood. The GHA transgene encodes a protein that inhibits the binding of GH to its receptor, specifically antagonizing the trophic effects of endogenous GH.

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