Collection of analytical data for benzodiazepines and benzophenones

On April 1st, 1986, amendments were made to Schedule 2 to the Misuse of Drugs Act 1971 such that 33 benzodiazepines became controlled as Class C drugs in the U.K. An analytical database has been prepared to aid the detection and identification of controlled benzodiazepines. Chromatographic properties have been measured including gas chromatography (GC) retention index values, high-performance liquid chromatography (HPLC) capacity factors and thin-layer chromatography (TLC) RF x 100 values. UV spectroscopic and mass spectrometric (MS) data have also been recorded. Analytical data (GC, TLC and MS) are also presented for benzophenones which were produced by acid hydrolysis of the parent benzodiazepines.