Multicomponent synthesis of spiroisoxazolines |
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| Authors: | Adamo Mauro F A Donati Donato Duffy Eleanor F Sarti-Fantoni Piero |
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| Institution: | Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland. madamo@rcsi.ie |
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| Abstract: | A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography. |
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