Propargylic amines constructed via copper-catalyzed three-component coupling of terminal alkynes, benzal halides and amines |
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| Authors: | Zhewang LinDingyi Yu Yugen Zhang |
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| Institution: | Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore |
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| Abstract: | A method for the synthesis of propargylic amines has been developed via an efficient copper(I)-catalyzed three-component coupling reaction of alkynes, benzal halides and amines through C-H and C-halogen activation. This reaction is conducted under mild conditions and provides an alternative method for the synthesis of propargylic amines. |
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| Keywords: | Alternative propargylic amine synthesis Copper-catalyzed AHA coupling |
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