Synthesis of amino acid derivative Schiff base copper(II) complexes by microwave and wet mechanochemical methods

As resource- and time-saving and environmentally friendly synthetic methods than conventional one in a solution, microwave, and wet mechanochemical synthesis are tested for l-amino acid derivative Schiff base copper(II) complexes. Herein, we systematically compared efficiency (low-temperature, time, and yield (if possible to detect)) for both conventional solution method and microwave or mechanochemical methods. The wet mechanochemical synthesis promoted fast reaction (typically 20 ​min by mechanochemical vs 4 ​h by conventional) by a little amount of solvent for preparations of amino acid derivative Schiff base copper(II) complexes. New crystal structure of a five-coordinated square pyramidal copper(II) complex as one of the products of microwave method was also reported.