Facile synthesis of superparamagnetic manganese ferrite nanoparticles as a novel T2 MRI contrast agent |
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Institution: | Research Institute of Medicine and Pharmacy, Qiqihar Medical University, China |
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Abstract: | With co-precipitation method we successfully synthesized an aqueous dispersible, superparamagnetic manganese ferrite nanoparticles at relatively low temperature (190 °C). This material shows potential application as T2 MRI contrast agent. Cost-effective and less toxic manganese (II) chloride (MnCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used as precursors and 2-2-(2-Hydroxyethoxy)ethoxy] ethanol (TEG) were utilized as solvent which served as stabilizer and provided a reduction system. The mean diameter of these nanoparticles is about 7 nm. Its saturation magnetization (Ms) and relaxivity value (r2) are as high as 46 emu/g and 593.9 mM−1s−1 respectively. In vitro cell study demonstrated pancreatic cancer cells could keep viable when the manganese ferrite nanoparticles concentration reached up to 50 μg/mL. |
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Keywords: | Superparamagnetic Manganese ferrite nanoparticles |
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