基于石墨烯纳米材料的DNA测序研究进展

设计和研发快速、准确、价廉、高通量的DNA测序方法,对于预防早期疾病和了解相关疾病机理具有非常重要的意义。新型纳米材料石墨烯由于具有独特的结构和性质,在化学和生物科学等领域发挥着重要的作用。该文介绍了DNA测序的研究现状以及应用石墨烯纳米材料的优势,重点阐述了DNA链通过石墨烯纳米孔、石墨烯纳米间隙、石墨烯纳米带时产生不同的电流信号识别碱基序列的原理,同时介绍了DNA链与石墨烯的相互作用对DNA测序的影响,并对DNA测序的研究方向进行了展望。该文为基于石墨烯纳米材料的DNA测序提供了作用原理、理论研究以及检测方法等参考。

Progress in DNA Sequencing Based on Graphene Nanomaterials

Design and development of fast,reliable,cheap and high throughput DNA sequencing could be the most revolutionary significance for preventing early disease and understanding the mechanisms of related diseases.Due to its distinctive structures and properties,the new nanomaterials graphene is playing an important role in many areas such as chemistry and bioscience.In this review,we describe the research states of DNA sequencing and the advantages of the application of graphene nanomaterials.The different current signals generated by DNA chains through graphenenanopore,graphenenanogap and graphene nanoribbon to identify base sequences are discussed in detail.The effect of interaction between DNA chains and graphene on DNA sequencing isfurther discussed,and the future research of DNA sequencing is also prospected.It provides referencesof working principle,theoretical research and detection methods of DNA sequencing based on graphene nanomaterials.