Iterative, aqueous synthesis of beta3-oligopeptides without coupling reagents |
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| Authors: | Carrillo Nancy Davalos Eric A Russak Justin A Bode Jeffrey W |
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| Institution: | Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9510, USA. |
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| Abstract: | The chemoselective synthesis of amides by decarboxylative couplings of alpha-ketoacids and isoxazolidines makes possible an iterative approach to poly-beta3-peptides. Peptide assembly occurs under aqueous conditions and requires no coupling reagents. The requisite isoxazolidine monomers are prepared in enantiopure form by a convenient two-step protocol starting from the appropriate aldehydes. |
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