Conformational studies of some 2-phenylpropyl derivatives by NMR spectroscopy and use of lanthanide shift reagents |
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Authors: | SL Spassov R Stefanova |
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Institution: | Institute of Organic Chemistry, Bulgarian Academy of Sciences, 1113 SofiaBulgaria |
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Abstract: | The conformational distribution of CH3CH(Ph)CH2X (X = OH, OCH3, NH2 Cl) has been studied by NMR and IR spectroscopy. The results are interpreted in favour of the conformers with methoxy- or chloro-groups anti to the phenyl group, but the amino group anti to the methyl group. For the alcohol both forms are about equally populated. It is suggested that intra-molecular hydrogen bonding might be affecting the conformational equilibria when X = OH, NH2. |
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