| 碳纳米管为基质对氨基酸的MALDI-FT MS分析 |
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| 引用本文： | 张菁,王昊阳,郭寅龙. 碳纳米管为基质对氨基酸的MALDI-FT MS分析[J]. 中国化学, 2005, 23(2): 185-189. DOI: 10.1002/cjoc.200590185 |
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| 作者姓名： | 张菁 王昊阳 郭寅龙 |
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| 作者单位： | ShanghaiMassSpectrometryCenter,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 摘 要： | Twenty common amino acids have been analyzed successfully by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using carbon nanotubes as matrix. From the spectra, little or no background interference or fragmentation of the analytes has been observed. This method was also applied to the analysis of amino acid mixture successfully. Carbon nanotubes have some features such as large surface area to disperse the analyte molecules sufficiently and prevent the sample aggregation and strong ultraviolet absorption to transfer energy easily to the analyte molecules. The present method has potential application for the rapid and sensitive analysis of amino acids and their mixture.
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| 关 键 词： | 氨基酸 MALDI-FTMS 生物大分子 生物化学分析 碳纳米棒 气相色谱 液相色谱 |
| 收稿时间： | 2004-02-27 |
| 修稿时间： | 2004-10-27 |
Amino Acids Analysis by MALDI Mass Spectrometry Using Carbon Nanotube as Matrix |
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| Zhang Jing,Wang Hao-Yang,Guo Yin-Long. Amino Acids Analysis by MALDI Mass Spectrometry Using Carbon Nanotube as Matrix[J]. Chinese Journal of Chemistry, 2005, 23(2): 185-189. DOI: 10.1002/cjoc.200590185 |
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| Authors: | Zhang Jing Wang Hao-Yang Guo Yin-Long |
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| Affiliation: | 1. Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;2. Fax: 86-21-64166128 |
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| Abstract: | Twenty common amino acids have been analyzed successfully by matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) using carbon nanotubes as matrix. From the spectra, little or no background interference or fragmentation of the analytes has been observed. This method was also applied to the analysis of amino acid mixture successfully. Carbon nanotubes have some features such as large surface area to disperse the analyte molecules sufficiently and prevent the sample aggregation and strong ultraviolet absorption to transfer energy easily to the analyte molecules. The present method has potential application for the rapid and sensitive analysis of amino acids and their mixture |
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| Keywords: | amino acid MALDI‐FTMS carbon nanotube |
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