Synthesis of Methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates |
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Authors: | Velikorodov A. V. |
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Affiliation: | (1) Astrakhan State University Astrakhan, 414056, Russia |
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Abstract: | By alkylation of methyl-N-(4-hydroxyphenyl)carbamate with (chloromethyl)oxirane in acetone in the presence of K2CO3 methyl-N-[4-(2,3-epoxypropoxy)phenyl]carbamate was prepared. The aminolysis of the latter effected by benzylamine, morpholine, piperidine, and pyrrolidine occurs in keeping with Krasusky rule to afford methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates. |
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