Supramolecular recognition of estrogens via molecularly imprinted polymers |
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Authors: | Bogus?aw Buszewski Júlia Ri?anyová Renata Gadza?a-Kopciuch Micha? Szumski |
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Institution: | 1. Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87 100, Toruń, Poland 2. Department of Analytical Chemistry, Institute of Chemistry, Pavol Jozef ?afárik University, Moyzesova 11, 041 54, Ko?ice, Slovakia
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Abstract: | The isolation and preconcentration of estrogens from new types of biological samples (acellular and protein-free simulated
body fluid) by molecularly imprinted solid-phase extraction has been described. In this technique, supramolecular receptors,
namely molecularly imprinted polymers (MIPs) are used as a sorbent material. The recognition sites of MIPs were prepared by
non-covalent multiple interactions and formed with the target 17β-estradiol as a template molecule. High-performance liquid
chromatography with spectroscopic UV, selective, and a sensitive electrochemical CoulArray detector was used for the determination
of 17β-estradiol, estrone, and estriol in simulated body fluid which mimicked human plasma. |
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