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Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration |
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| Authors: | Bahman N Shokouhi Bernadette ZY Wong Samir Siddiqui A Robert Lieberman Gregor Campbell Koujiro Tohyama Patrick N Anderson |
| Affiliation: | (1) Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK;(2) Centre for Electron Microscopy and Bioimaging Research, Laboratory for Nano-Neuroanatomy, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka Iwate, 020-8505, Japan |
| Abstract: | BackgroundMicroglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons, which do not normally regenerate axons. We aimed to establish whether there was an inflammatory response around the perikarya of CNS neurons that were induced to regenerate axons through a peripheral nerve graft. |
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