Synthesis and HIV-1 RNase H-activity of new alizarin acetonyl derivatives |
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| Authors: | T. V. Kharlamova |
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| Affiliation: | (1) A. B. Bekturov Institute of Chemical Sciences, Republic of Kazakhstan, Almaty, ul. Sh. Ualikhanova, 106;(2) Department of Biomedical Science and Technology, University of Cagliari, Cagliari, Italy |
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| Abstract: | Alkylation of 1,2-dihydroxyanthraquinone (alizarin) by α-bromoacetone was studied and its β-acetonyl derivative was chemically modified. The composition and structure of the products were confirmed by elemental analysis; UV, IR, PMR, and 13C NMR spectroscopy; and mass spectrometry. The synthesized derivatives were tested as inhibitors of HIV-1 RNase H. |
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